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Indications: Tirzepatide is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Contraindications: Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). It should not be used in patients with a history of severe gastrointestinal disease, including gastroparesis.
Warnings and Precautions:
Adverse Reactions:The most common adverse reactions (≥5%) associated with tirzepatide include nausea, vomiting, diarrhea, abdominal pain, and constipation.
Pregnancy and Lactation: Tirzepatide should not be used during pregnancy as it may cause fetal harm. It is unknown whether tirzepatide is excreted in human milk, and caution should be exercised when administering tirzepatide to breastfeeding women.
Drug Interactions:Caution should be exercised when co-administering tirzepatide with other drugs that affect gastrointestinal motility or absorption, as well as drugs that may increase the risk of hypoglycemia.
Patient Counseling Information:Patients should be counseled on the risks and benefits of tirzepatide therapy, including the potential for gastrointestinal adverse reactions, hypoglycemia, and the importance of adherence to diet and exercise. Patients should also be educated on the signs and symptoms of thyroid tumors, pancreatitis, and hypersensitivity reactions.
For more information on Tirzepatide safety and efficacy, please visit HERE.