Discover how NAD+ (nicotinamide adenine dinucleotide) may boost energy production, mitochondrial function, and metabolic health for women between 35 and 55. Learn how Eden connects you with licensed healthcare providers offering personalized care plans that may include prescription NAD+ therapies tailored for midlife metabolic support.

• NAD+ plays a vital role in energy production, glucose metabolism, and cellular repair.
• NAD+ levels naturally decline with age, stress, and poor sleep, especially during hormonal changes in women aged 35–55.
• Supporting NAD+ may improve mitochondrial efficiency, metabolic stability, and stress resilience.
• Eden offers access to licensed healthcare providers who may recommend prescription NAD+ therapies as part of a comprehensive care plan.

Note: Supplements are not FDA evaluated and are not intended to diagnose, treat, cure, or prevent any disease.

Why NAD+ Is Essential for Metabolic Health in Women

NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme involved in over 500 enzymatic reactions that support cellular energy production, mitochondrial health, and circadian rhythm regulation. This coenzyme acts as a key player in metabolic pathways such as glucose metabolism and DNA repair.

Scientific studies show NAD+ influences enzymes like sirtuins and PARPs, which regulate aging processes and cellular stress responses. However, NAD+ levels tend to decline with age and lifestyle factors, potentially impairing metabolic function and energy levels, especially in women undergoing hormonal shifts during their midlife years.

Metabolic Changes in Women Ages 35–55 and NAD+ Decline

Women between the ages of 35 and 55 often experience notable metabolic shifts linked to perimenopause and menopause, including:

• Decreased exercise recovery
• Increased visceral fat accumulation
• Blood sugar fluctuations
• Energy instability and fatigue

These changes are often accompanied by increased oxidative stress and disrupted sleep patterns, both of which can reduce NAD+ availability and mitochondrial function.

While NAD+ therapies are not approved to treat hormonal or metabolic disorders, emerging research indicates that supporting NAD+ levels may help improve mitochondrial efficiency and stabilize metabolism during midlife transitions.

Recognizing Low NAD+ Symptoms in Midlife Women

Although there’s no clinical test to diagnose NAD+ deficiency, some women report symptoms potentially linked to decreased cellular NAD+ and mitochondrial performance, such as:

• Persistent, low-grade fatigue
• Energy “crashes” after meals
• Slower recovery from stress, both physical and emotional
• Feeling wired but tired simultaneously

These symptoms are non-specific and may result from a combination of factors, including hormonal fluctuations, stress, diet, and sleep quality. Early research continues to investigate how NAD+ supplementation could support energy metabolism and stress adaptation during these transitions.