You’ve hit your goal weight using a GLP-1 medication like semaglutide or tirzepatide. So now what? Should you stop taking it?  In many cases, the answer is: not necessarily.

GLP-1s aren’t just weight-loss tools — they’re also powerful weight maintenance tools. Continuing them may help prevent weight regain, preserve metabolic improvements, and support your long-term health.

Why Continue GLP-1s?

Think of GLP-1s like you would blood pressure medication. You wouldn’t stop taking it just because your numbers look good — they look good because the treatment is working.

Ongoing GLP-1 use can help stabilize appetite, maintain satiety, and prevent the yo-yo pattern of weight loss followed by regain. If you're tolerating your medication well and don’t have any new health issues, many healthcare providers recommend staying on it.  If GLP-1s helped reset your appetite and metabolism and you’ve historically struggled with weight, continuing therapy long-term can be a smart, sustainable solution.

What Happens If You Stop?

You can stop, but be aware: stopping GLP-1s often leads to weight regain. In fact, a 2022 study on Wegovy® showed that people regained about two-thirds of the weight they lost within a year of stopping.

Why? Hunger cues and cravings typically return, and metabolic shifts may make it easier to gain weight back — especially without structured support or lifestyle changes in place.

Other health benefits, like improved blood sugar or cardiovascular markers, may also decline after stopping.

Thinking of Stopping? Talk to Your Provider

If you're considering coming off GLP-1s, connect with your provider first. They can help you taper safely and recommend strategies — like a tailored nutrition and activity plan — to support weight maintenance.

Managing Side Effects

If you’re still experiencing side effects even after hitting your goal weight (like nausea, fatigue, or GI issues), you don’t need to push through. You may benefit from a lower dose or switching medications.

Your provider can help find a more comfortable maintenance plan — one that works for your body and lifestyle.

Long-Term Safety of GLP-1s

GLP-1s were originally developed for long-term use in people with type 2 diabetes. Millions have now used them safely for weight loss, too.  So far, studies show they're generally safe over extended periods. A 2024 review found Wegovy® was well tolerated over two years. Another study followed people with obesity and heart disease using GLP-1s for four years with no major safety issues.

What to Do If You Hit a Plateau or Start to Regain

Even with GLP-1s, plateaus and minor regain can happen. If the scale stalls or starts to creep up, consider:

• Boosting protein intake: Aim for about 100g/day (or personalize it). Protein helps you stay full and maintain lean muscle.
• Moving more: Even light movement like walking or housework can help.
• Improving sleep: Poor sleep increases appetite and cravings.
• Managing stress: Chronic stress can derail weight goals. Find ways to unwind that work for you.

Also, don’t hesitate to check in with your provider. A dosage adjustment or added support may get you back on track.

GLP-1s don’t have to be a short-term solution. For many people, they’re a safe and effective long-term tool for keeping weight off — and keeping health gains going.

Before making any changes, check in with your provider. A personalized maintenance plan can help you stay feeling your best.